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Take the I-5 if you want to get there fast. You might want to take the BART train to '''Dublin/Pleasanton'''. The BART station is located next to a highway onramp, but you might have better luck if you walk further East to the following onramp. (You're actually hitching onto I-580 here but it merges into I-5 further out.)
This route worked really well for an anonymous user in 2009: Take BART south to Milbrae. Change onto Caltrain, take that to San Jose for maybe about $7. Take VTA bus 68 to Gilroy from there, 1 hour 20 minutes, $1.75. Hitchhike east along the Pacheco Pass highway, which leads towards I-5; many cars here will be continuing south to Los Angeles on I-5. If heading towards Las Vegas, get off I-5 at exit 257, to get onto highway 58. Take that East, avoid getting stuck in Bakersfield. 58 goes all the way through, past Mojave and Barstow, towards Vegas. A note regarding Caltrain: tickets often aren't checked, but fare inspectors do come through occasionally and if caught without a ticket the fine is nearly $400, so think twice before risking it.
If you're considering taking a bus: booking far in advance you can sometimes find Megabus tickets from San Francisco to Los Angeles for as little as $1.50, though it's usually at least $10.