★★★☆☆

Strolled around a bit to find a good spot, then just stood at the gas station exit to the motorway with a Praha sign for 30 minutes. Very few cars going through the gas station, but in my opinion still the best bet going West from Brno since all cars go in the direction of Prague. Eventually got picked up by an extremely nice Slovakian/Ukrainian couple and got dropped off exactly where I wanted to go in Prague. About reaching the gas station: like the hitchhiker before me, I drove to the station with the train (two stops, S4/S41), then went along the street to the bridge under the motorway. Climbed up the steep hill next to the bridge and walked 500 m alongside the motorway (outside the railing!!) to the gas station. Not the best spot to reach, but very doable and a lot easier than I imagined after reading the other comments